Compounding Studies
There have been many studies on “bio-identical” hormones. Bio-identical hormones include Estriol, Estradiol, Progesterone, Testosterone and DHEA. The following are a few citations from recognized medical journals.
“…HRT use in women with a family history of breast cancer is not associated with a significantly increased incidence of breast cancer but is associated with a significantly reduced total mortality rate.”
The role of hormone replacement therapy in the risk for breast cancer and total mortality in women with a family history of breast cancer.: Sellers, Mink, Cerhan, Zheng, Anderson, Kushi, Folsom; Division of Epidemiology, University of Minnesota, Minneapolis; ACP J Club. 1998 May-Jun;128(3):74: PMID: 9412302 (PubMed – indexed for MEDLINE)
“Estrogen replacement therapy apparently does not increase either recurrences or mortality rates [of breast cancer]. Adding progestogens may even decrease recurrences [of breast cancer].”
Estrogen replacement therapy in women with previous breast cancer.: Natrajan, Soumakis, Bambrell Jr.; Department of Physiology, Medical College of Georgia, Georgia; Am J Obstet Gynecol. 1999 Aug;181(2):288-95. Pmid: 10454671 (PubMed – indexed for MEDLINE)
“Women who have had a simple hysterectomy (ovaries remaining intact), even if treated post-surgically with supplementary estrogen, have three times the risk of cardiovascular disease compared with women who have not had a hysterectomy….. Restoring a physiologic level of testosterone to women after hysterectomy not only can improve quality of life in terms of sexual libido, sexual pleasure, and sense of well-being but also can build bones – and may be a key to protecting cardiovascular health.”
Testosterone deficiency: a key factor in the increased cardiovascular risk to women following hysterectomy or with natural aging?: Rako: J Womens Health. 1998 Sep;7(7): 825-9 PMID: 9785308 (PubMed – indexed for MEDLINE)
“Hysterectomy has a potential for generating serious consequences in terms of health, including two to seven times greater incidence and prevalence of cardiovascular disease, and quality of life, including loss of sexual libido and pleasure. Testosterone supplemental therapy for women following hysterectomy not only can improve the quality of their lives in terms of sexual libido, sexual pleasure, and sense of well-being but also can – as does supplementary estrogen – contribute to the prevention of osteoporosis. Most importantly, an increasing body of evidence suggest that testosterone may be cardiovascular protective. …..testosterone deficiency in women may be costing more in morbidity and mortality than we know at present.”
Testosterone supplemental therapy after hysterectomy with or without concomitant oopherectomy: estrogen alone is not enough.: Rako; J Womens Health Gend Based Med. 2000 Oct;9(8):917-23: PMID: 11074958 (PubMed – indexed for MEDLINE)
“Postmenopausal women (PMW) have increased incidence of cardiovascular disease, and estrogen substitution therapy has been shown to have cardioprotective effects.”
17Beta-estadiol, its metabolites, and progesterone inhibit cardiac fibroblast growth.: Dubey, Gillespie, Jackson, Keller; Department of Medicine, University of Pittsburg Medical Center, PA; Hypertension. 1998 Jan;31(1 Pt 2):522-8: PMID:9453356 (PubMed – indexed for MEDLINE)
“…results demonstrated the stimulatory role of progesterone in combination with Estradiol in bone formation and mineralization.”
Influence of estrogen and progesterone on matrix-induced endochondral bone formation.: Burnett, Reddi; Calcif Tissue Int. 1983 Jul;35(4-5):609-14. PMID: 6616325 (PubMed – indexed for MEDLINE)
“Sublingual micronized HRT favorably decreases serum and urine markers of bone metabolism, prevents bone loss, and results in a slight increase in spine and hip bone mineral density.”
Sublingual administration of micronized Estradiol and progesterone, with and without micronized testosterone: effect on biochemical markers of bone metabolism and bone mineral density.: Miller, DeSuza, Slade, Cuciano; Center for Fertility and Reporductive Endocrinology, New Britain General Hospital, Connecticut; Menopause. 2000 Sep-Oct;7(5):318-26. PMID:10993031 (PubMed – indexed for MEDLINE)
“…progesterone may represent a mechanism for the hormone’s protective effect against atherosclerosis.”
Progesterone inhibits arterial smooth muscle cell proliferation.: Lee, Harder, Yoshizumi, Lee, Haber; Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusets; Nat Med. 1997 Sep; 3(9):1005-8. PMID:9288727 (PubMed – indexed for MEDLINE)
“Estrogen specifically maintains verbal memory in women and may prevent of forestall the deterioration in short- and long- term memory that occurs with normal aging. There is also evidence that estrogen decreases the incidence of Alzheimer disease or retards its onset or both.”
Can estrogen keep you smart? Evidence from clinical studies.: Sherwin; Department of Psychology, McGill University, Montreal, Que.; J Psychiatry Neurosci. 1999 Sep; 24(4):315-21. PMID:10516798 (PubMed – indexed for MEDLINE)
“Pharmacists can educate women about the various mood and memory changes that can occur during perimenopause and how estrogen replacement therapy may lead to improvements in brain function. The potential use of estrogen replacement therapy to reduce risk of Alzheimer’s disease and ease the symptoms of Parkinson’s disease could hav a profound effect on women, their families, and society as a whole.”
Effects of estrogen on cognition, mood, and degenerative brain disease.: Shepherd; J Am Pharm Assoc (Wash). 2001 Mar-Apr;41(2):221-8. PMID:11297335 (PubMed – indexed for MEDLINE)
“[using estriol replacement therapy] 75% of the women reported significant subjective improvement of stress incontinence.”
Effects of protracted administration of estriol on the lower genitor urinary tract in postmenopausal women.: Iosif; Department of Obstetrics and Gynecology, University of Lund, Sweden; Arch Gynecol Obstet. 1992;251(3):115-20. PMID:1605675 (PubMed – indexed for MEDLINE)
“The intravaginal administration of estriol prevents recurrent urinary tract infection in postmenopausal women….”
A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections.: Raz, Stamm; Infectious Disease Unit, Central Emek Hospital, Afula, Isreal. N Engl J Med. 1993 Sep 9;329(11):753-6.
